Abstract: Achieving compliance with upcoming Euro 7 and EPA 2027 emission standards require diesel aftertreatment systems that are not only efficient but also adaptive to diverse real-world conditions. Conventional fixed-schedule DPF regeneration strategies remain limited by their rigidity, often leading to excessive fuel use, thermal stress, and premature filter degradation. Addressing these limitations, this study introduces a biomimetic regeneration control framework inspired by the kidney’s homeostatic regulation—a natural model of adaptive stability and self-maintenance.