Abstract: Cyperus rotundus Linn belong to the family Cyperaceae. It is the world worst weed native to India. It grows in small clump up to 100cm high. The extensive distribution of the nut-grass is due to its ability to adapt to a wide range of soil types, altitudes, temperatures, soil pH and moisture levels. It therefore grows in a variety of different habitats and environments. It has wide range of medicinal and pharmacological applications. According to the Ayurveda, C.rotundus rhizomes are considered astringent, diaphoretic, diuretic, analgesic, antispasmodic, aromatic, carminative, antitussive, emmenagogue, litholytic, sedative, stimulant, stomachic, vermifuge, tonic and antibacterial. This paper provides review on medicinal uses and various pharmacological properties of C.rotundus rhizome.