Abstract: Meningioma is one of the intracranial primary tumors that often occurs with the incidence in the United States covering 36% of all tumors in the central nervous system. The growth of solid tumors such as meningiomas is highly dependent on angiogenesis. Vascular Endothelial Growth Factor (VEGF) and Fibroblast growth Factor-2 (FGF-2) are angiogenic factors that mediate positive regulation for angiogenesis. Both VEGF and FGF-2 examinations in previous meningioma have been carried out, but using blood serum samples.