Abstract: The increase of Prostate Specific Antigens levels and It’s effect on patient’s complete blood count was carried out in Okigwe Imo State. A total of 200 patients were examined Blood specimen was collected aseptically using standards microbiological laboratory techniques. The patients were examined for, prostate specific Antigen (PSA) (quantitative) and complete blood count (CBC) tests. Out of 200 patients tested for PSA level in study area, 119 (59.5%) patients were positive with PSA level of 4.0ng and above and 81(40.5) patients were negative with PSA level below 4.0 ng/ml. 71-80 years of age had the highest number of positive PSA of 45(21.0) while 21-30 years of age were all negative to PSA testing.