Abstract: Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease. The hallmark feature of SLE is chronic inflammation that affects the skin, joints, kidneys, lungs, nervous system, serous membranes such as the pleura and pericardium, mucous membranes and other organs of the body. Oral lesions of lupus erythematosus show an array of clinical aspects and most affected sites are lips and buccal mucosa [1, 2]. This case report presents a clinical profile of a patient with SLE along with different oral lesions. This article highlights methods to recognize and manage the oral manifestations of this systemic disease.