Abstract: Sclerotium rolfsii Sacc. is known to be a serious pathogen on many crops of economic importance. This pathogen is the major constraint in successful cultivation of most of the cash crops in Barak Valley. The present investigation was carried out to evaluate the potential of six systemic fungicides (i.e. Propiconazole 25% EC, Hexaconazole 5% EC, Mycobutanil 10% WP, Thiophanate Methyl 70% WP, Tebuconazole 25.9 m/m EC & Carbendazim 50%WP); three non-systemic fungicides(i.e. Captaf, Mancozeb 75%WP & Copper oxychloride) and three combo fungicides(i.e. Metalaxyl 8% +Mancozeb 64% , Carbendazim 12% + Mancozeb 63% & Carboxin 37.5% + Thiram 37.5%). These fungicides were evaluated at different concentrations (i.e. 1, 10, 50 and 100 ppm), except copper-oxychloreide (contact) at 0.1%, 0.25%, 0.5% and 1.00% on the growth of Sclerotium rolfsii in Potato dextrose agar (PDA) medium using poisoned food technique, in vitro. The result shows that the effect of hexaconazole (systemic) has been highly effective in suppressing radial expansion as well as percent inhibition of the fungus at all the concentrations used followed by Carboxin 37.5% + Thiram 37.5%(combo Fungicide) and tebuconazole (systemic). The results suggest that some of these fungicides may be tried against S. rolfsii in susceptible crop plants (i.e. brinjal) under field condition.