Abstract: Objective: N-acetyl-cysteine (NAC), a mucolytic drug with insulin sensitizing properties, has been proved useful as an adjuvant therapy in subjects with infertility due to anovulation associated with polycystic ovarian syndrome The objective of the present study is to determine the possible beneficial effect of NAC and to develop a rationale to its use in such cases as an adjunct to clomiphene citrate (CC) which remains the gold standard for ovulation induction.