Abstract: A series of ethyl N-(cyclohexyl(methyl)amino)-2oxoindolin-3-ylideneamino)(4-fluorophenyl)methylformimidate derivative (8a-8e) were prepared by the reaction of ethyl N-substituted 2-oxoindolin-3-ylideneamino)methylformimidate 6 and N-methylcyclohexanamine 7 to passing HCl/H2S through solution of substituted 4- substituted isocyano methanamine 1 and absolute ethanol. Ethyl N-(4- substituted)(-2-oxoindolin-3-ylideneamino)methylformimidate 6 were synthesized from the reaction of synthesized compound ethyl N-amino(4-substituted)methylformimidate 4 and isatin(1-H, indole 2,3-dione) are added to each other and finally compound (6a-6e) were form. This reaction known as Schiff reaction. The spectral study of newly synthesized compounds was characterized on the basis of elemental analysis, IR, H1 NMR, 13C-NMR and mass spectra.