Abstract: The study aimed to evaluate the effect of metformin and the combined activity of P. daemia and metformin in the treatment of polycystic ovary syndrome (PCOS) induced rats. Female albino wistar rats (150- 180 g) were injected with Testosterone propionate (TP) for the development PCOS. The PCOS induced rats were divided into two groups, one were treated with metformin and the other were treated with the combination of metformin and Pergularia daemia extract over a period of 15 days. The vaginal smear and histological studies proved the combined efficacy of metformin and the P. daemia extract by restoring the estrous cycle and re-establishment of the ovarian morphology. The biochemical and hormonal assays also confirms the same. Thus we conclude that the combined activity of metfromin and P. daemia extract is an effective medicine in treating PCOS than metformin alone.