International Journal of Scientific and Research Publications

IJSRP, Volume 5, Issue 11, November 2015 Edition [ISSN 2250-3153]


Evaluation of Pergularia daemia and metformin in the treatment of PCOS in testosterone propionate induced albino wistar rats (Rattus norvegicus)
      R. Poornima, P. Saranya, S. Bhuvaneshwari, Dr. Horne Iona Averal
Abstract: The study aimed to evaluate the effect of metformin and the combined activity of P. daemia and metformin in the treatment of polycystic ovary syndrome (PCOS) induced rats. Female albino wistar rats (150- 180 g) were injected with Testosterone propionate (TP) for the development PCOS. The PCOS induced rats were divided into two groups, one were treated with metformin and the other were treated with the combination of metformin and Pergularia daemia extract over a period of 15 days. The vaginal smear and histological studies proved the combined efficacy of metformin and the P. daemia extract by restoring the estrous cycle and re-establishment of the ovarian morphology. The biochemical and hormonal assays also confirms the same. Thus we conclude that the combined activity of metfromin and P. daemia extract is an effective medicine in treating PCOS than metformin alone.

Reference this Research Paper (copy & paste below code):

R. Poornima, P. Saranya, S. Bhuvaneshwari, Dr. Horne Iona Averal (2018); Evaluation of Pergularia daemia and metformin in the treatment of PCOS in testosterone propionate induced albino wistar rats (Rattus norvegicus); Int J Sci Res Publ 5(11) (ISSN: 2250-3153). http://www.ijsrp.org/research-paper-1115.php?rp=P474822
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