Abstract: The extracts of Moringa oleifera leaf have been proven to have potent anti oxidant activity, prevent oxidative damage and afford significant protection against oxidative damage. This study aims to assess the effect of Moringa oleifera leaf extracts supplementation in preventing maternal oxidative DNA damage. This was a double bind, randomized control trial study, which conducted in Gowa District, South Sulawesi Province, Indonesia, from January to December 2012. Seventy six of first trimester pregnant women enrolled in this study. They were randomized equally to the intervention and control group.