Abstract: The North Africa region is characterized by countries that have common cultures and religion and that are more conservative sexual behavior compared to Occidental countries. In this paper, we provide the available information on the burden of Human papillomavirus (HPV)-related cancers (cancer of the cervix, anal cancer, vaginal cancer, vulvar cancer and cancer of the pharynx), as well as available data on the prevalence and distribution of HPV types among men and women with an HPV related cancer, for the countries of the North Africa region (NA). The countries in the NA region show a generally low incidence of cervical cancer (ASR: 6.6/100,000). HPV prevalence (%) in the general population women with normal cytology varied from 10.3 in Egypt to 14.6 in Tunisia.