Abstract: Rhinitis, an extremely common medical condition, is characterized by acute or chronic inflammation of mucous membranes. Pro-inflammatory cytokines, including interleukin-6 (IL-6), IL-8 and TNF-α are the key drivers of inflammatory response in rhinitis. Hence, their inhibition is an important therapeutic strategy for treating rhinitis. In vitro cell line models are extremely valuable for testing the potential of new therapeutic compounds. Epithelial cell lines derived from the airway and nasal passage have been previously reported as models for testing anti-rhinitic drugs such as Cetirizine and Loratidine.