Abstract: Oral pregabalin premedication adequately sedates the patient and haemodynamic pressor response of airway instrumentation was attenuated Material and methods: The study was designed as a prospective randomized, double-blinded,placebo controlled study, which included 120 normotensive adult patients aged 24-56years of both genders,scheduled for elective surgery under general anaesthesia with ASA physical status I & II were allocated for the study.This study was done in the department of anaesthesia, and critical care,Sher-i-Kashmir institute of medical science, Srinager( J &K) after obtaining approval from ethical committee,a written informed consent was taken from the patients for participation in this study.Results: Systolic blood pressure increased maximally in group I(P0) and group II(P75) 1min after direct laryngoscopy and endotracheal intubation from baseline (32.1% from baseline).It gradually decreased to near baseline values over 10 minutes.In groupIII (P150) maximum rise in blood pressure was 11.1% from baseline.Among these only pregabalin 150mg attenuated the rise in blood pressure following laryngoscopy(p-value=0.001).