Abstract: Acute infection with parvovirus B19 is responsible for blocking erythroblasts and is usually without consequences on hematopoiesis, except in patients with chronic hemolytic anemia.it causes a potentially serious acute anemia. We report the case of an 18 year-old sickle cell patient with this infection revealed by erythroblastopenia. He was hospitalized for fever and headache. The Laboratory tests showed a non-regenerative anemia and hemolysis. We concluded to the diagnosis of erythroblastopenia secondary to infection with parvovirus B19 because of the presence of IgM and parvovirus DNA on PCR. The evolution was favorable after transfusion. Any erythroblastopenia in a sickle cell patient should alert the clinician to a possible parvovirus B19 infection.