Abstract: Background: HIV- infected patients are at high risk of colonization and infection with methicillin resistant Staphylococci over the past decade. Increasing non-β-lactam antimicrobial resistance among methicillin resistant Staphylococcal clones, particularly to clindamycin, may complicate the efforts to manage infections in the community. Methodology: Nasal swabs from 200 HIV patients were cultured. Staphylococcal isolates were tested for methicillin resistance by Cefoxitin disk diffusion test & inducible clindamycin resistance by D test as per CLSI guidelines. CD4 counts of the patients were determined and analyzed.