Abstract: Chronic dialysis imposes a considerable burden on patients and families. Psychosocial issues are an important concernin the overall health of haemodialysis patients. Over recent years, there has been increasingattention given to the individual characteristics of patientswith an emphasis placed on understanding the effects of the patient social situation, perceptions and responses to the illness,their physicians and healthcare providers, their spouses andfamilies, and their socio economic status have on outcomes. This study sought to assessthe influence of illness perception on depression and quality of life in haemodialysis patients. The sample included 31 males and 21 females with the age range of 20 -60 years and illness duration of 1year to 5 years. Patients were evaluated with comprehensive psychological testing. Result shows that there was significant relationship found between depression and quality of life in relation to illness perception. Understanding of illness was significantly different in male and female haemodialysis patients.