Abstract: The purpose of this paper is to study the relationship between rewards, and performance of Health Centre IV workers in greater Mbarara District. The constructs of rewards include; salary, performance bonus, recognition and promotion. This study used cross-sectional, explanatory and correlational approaches. Health center IV workers data were collected by means of a questionnaire survey from a sample of 200 health workers from 11 health centres from greater Mbarara district. Structural equation modelling was used to test the hypotheses.