Abstract: This preliminary study was conducted to evaluate the microbiological quality of paediatric oral liquid drug formulations during consumption. Paracetamol, Salbutamol, Cephalexin, Amoxicillin and Lactulose are few oral liquid medicines prescribed in Sri Lanka. These oral liquid medicines are at a greater risk of microbial contamination during consumption. This can lead to co-infection in paediatric patients. Therefore, it is important to evaluate microbial quality of oral liquid medicines during consumption. In methodology, organoleptic examination, pH determination and assessment of microbiological quality of two bottles from each five commercially available samples were done. Selective media were employed for quantification and isolation of the microbial contaminants.