Abstract: Obesity is a global epidemic disease and is recognized as a major public health problem in India. Urbanization, Improved economical status, modernization and sedentary life style are some of the factors thought to underlie the epidemic. There is immediate need to treat the issue as Obesity is the major causative factor for many non-communicable diseases. The important strategies for weight management would be diet and Physical activity. But recently many other treatments evolved like behavior modification, weight loss nutritional supplements, non clinical weight management programs, medically managed weight-loss and surgical treatment. L-Carnitine, a vitamin like substance naturally synthesized in our body has gained much importance as weight loss nutritional supplement in treating Obesity as L-carnitine plays an important role in our body to transport fatty acids for its oxidation. As any other vitamin L-Carnitine is also naturally present in foods and the most in animal foods. Hence the study was undertaken to compare the rate of weight loss among overweight and obese individuals after supplementation of L-Carnitine (1000mg/day) for 30 days.