Abstract: At present the Tuberculosis (TB) Management had much attention on microbiological cure, and its impact on HRQOL is undervalued. The study was aimed to assess HRQOL including psychological, general health perception among TB patients. A prospective interventional study was conducted among 52 patients visiting department of chest and TB (IPD & OPD), Gulbarga Institute of Medical Science’s, Kalaburagi, for a period of 6 months. The data was collected by face- to –face interview and a suitably designed questionnaire world health organization quality of life (WHOQOL - BREF) and SF-36 questionnaire were used to assess the HRQOL of TB patients at base line before intervention and 2 months after the intervention using a pre-test design.