Abstract: Waste generation is un-avoidable in Hospital, 85% is general waste and remaining 15% is hazardous materials. Types of wastes generated are infectious waste, pathological waste, sharps waste, chemical waste, pharmaceutical wastes, cytotoxic wastes, radioactive wastes, non-hazardous or general waste. Life Cycle Approaches (cradle to grave) of waste management are waste avoidance, waste minimization, segregation, collection, transportation, storage, treatment and disposal. A qualitative study was done to analyze the waste management at a tertiary care hospital in Sri Lanka. High-income countries generates hazardous waste on average up to 0.5 kg of per hospital bed per day, while the average hazardous waste generation in low-income countries is 0.2 kg per bed per day, whereas in this study waste generation was 0.276 kg per bed per day.