Abstract: Self-care management, including the physical and psychological aspects, affects health and wellness. In vitro fertilization, lifestyle factors affect the production of oocytes, fertilization rates, miscarriage and pregnancy. The aim of study to assess the effectiveness of the instructional program on the women knowledge undergoing in-vitro fertilization/intracytoplasmic injection about self-care management A Study and Control Groups, Pre-Test and Post-Test (Quasi Experimental Design), were used to study the Effectiveness of Self-Care Management Instructional Program on Women’s Knowledge undergoing In-Vitro Fertilization , from the period of 17th September 2018 to 4th July 2019.