Abstract: Antibiotic prescription after simple extraction of tooth has remained a controversial topic amongst dental fraternity owing to the fact that antibiotic resistance is becoming a serious public health and patient safety issue. A prospective clinical trial was undertaken to assess the rationale behind antibiotic use after simple extractions in minimizing post extraction pain and discomfort. Materials and methods: All the patients undergoing simple extractions were categorized into two groups: Group 1: patients receiving antibiotics postoperatively, Group 2: patients not receiving antibiotics postextraction. The patients were evaluated upto 6 postextraction days for signs of infection and dry socket. Results: 4 patients (1.2%) reported with infection of the extraction socket in nonantibiotic group, whereas 1 (0.3%) case of infection was found in the antibiotic group. Dry socket was seen in 29 (8.8%) patients, 16 (4.8%) in the antibiotic group and 13 (3.9%) in the nonantibiotic group. Conclusion: The results of the present study do not significantly justify the use of antibiotics following extractions.