Abstract: Cattle suffering with plastic foreign body syndrome were treated surgically by rumenotomy. The pre-operative and 12th day post operative blood and serum biochemical were recorded and compared with normal healthy cattle. Pre-operatively decrease in haemoglobin, packed cell volume and total erythrocyte count was observed which was gradually increased and came to near normal state on 12th post-operative day. There was leucocytosis, neutrophilia and corresponding lymphopenia observed in animals during pre-operative phase. The glucose, serum creatinine, serum albumin and calcium levels were found to be at lower level and total proteins, blood urea nitrogen and phosphorus at higher level in pre-operative period when compared to normal cattle. This may be due to low intake of food and water and also inflammatory condition in body due to presence of plastic foreign body.