International Journal of Scientific and Research Publications

IJSRP, Volume 3, Issue 8, August 2013 Edition [ISSN 2250-3153]


A Convenient Method of Synthesis of 2-(Substituted Phenyl)-4-(4-Dimethylaminophenyl)-5-Phenyl-1H-imidazoles from4-Dimethylaminobenzil in the Absence of Catalyst
      D.S.Ambadkar, R.M.Kedar
Abstract: In this study new imidazoles derivatives were synthesized.The first stage involved preparation of 2-hydroxy-1-(4-dimethylaminophenyl)-ethan-1-one ( F1) by reacting 4-dimethylaminobenzaldehyde with benzaldehyde in presence of sodium cyanide catalyst .The second stage involved the synthesis of 1-(4-dimethylaminophenyl)-2-phenylethan-1,2-dione(f2) using nitric acid in glacial acetic acid. Finally the compound (5a-5l) were synthesized using the three component system ( Compound F2 , Substituted benzaldehyde and ammonium acetate ) .The structure of all compounds were confirmed by elemental analysis ,NMR and IR data and by melting point .In conclusion this method give some advantages such as good yield ,simple procedure , low cost of chemicals and easy work up .

Reference this Research Paper (copy & paste below code):

D.S.Ambadkar, R.M.Kedar (2018); A Convenient Method of Synthesis of 2-(Substituted Phenyl)-4-(4-Dimethylaminophenyl)-5-Phenyl-1H-imidazoles from4-Dimethylaminobenzil in the Absence of Catalyst; Int J Sci Res Publ 3(8) (ISSN: 2250-3153). http://www.ijsrp.org/research-paper-0813.php?rp=P201646
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