IJSRP, Volume 3, Issue 8, August 2013 Edition [ISSN 2250-3153]
Caglar Yildiz, Ali Cetin, Fatih Demirci, Zubeyde Akin Polat, Tuba Kiyan, Ahmet Altun, Meral Cetin, Ozlem Kayim Yildiz, Ismihan Goze
Angiogenesis that plays important roles in a variety of physiological processes is strictly delimited and finely tuned by a balance of pro-angiogenic and anti-angiogenic factors. Angiogenesis is essential for viability, growth, invasion and metastasis of tumors. The chorioallantoic membrane model is considered to be a valuable method for investigation of anti-angiogenic effects of drugs and other substances. The aim of the present study is to investigate the anti-angiogenic effects of a calcium channel blocker (diltiazem), a tyrosine kinase inhibitor (imatinib), and a vascular endothelial growth factor inhibitor (bevacizumab) with the means of the chicken chorioallantoic membrane (CAM) model.
Caglar Yildiz, Ali Cetin, Fatih Demirci, Zubeyde Akin Polat, Tuba Kiyan, Ahmet Altun, Meral Cetin, Ozlem Kayim Yildiz, Ismihan Goze (2018); Anti-Angiogenic Effects of Diltiazem, Imatinib, and Bevacizumab in the CAM Assay;
Int J Sci Res Publ 3(8) (ISSN: 2250-3153). http://www.ijsrp.org/research-paper-0813.php?rp=P201629