IJSRP, Volume 3, Issue 8, August 2013 Edition [ISSN 2250-3153]
Dr. M.S.Kusumadevi, Dr. K.M.Prassanna Kumar, Dr. P.Vijayakumar
Objective: The study was done with the purpose of evaluating the adrenal cortical response to 1 microgram ACTH stimulation test in children with type-1 diabetes and compared with that of controls.
Design: Case – control study. 28 children with type – 1 diabetes attending the outpatient department of endocrinology department, M.S.Ramaiah Medical College and Teaching Hospital and 20 age and sex matched controls from Happy Home Orphange, KGF were infused with 1µg ACTH.
Methods: Cortisol levels were estimated using radio immunoassay technique, before and 30 minute after 1 µg ACTH infusion.
Results: The cortisol levels significantly increased in normal as well as children with type – 1 diabetes. But the increase was not found to be the same in both the groups. The effect of ACTH in increasing cortisol levels is much more in normal as compared to children with type-1 diabetes.
Conclusion: The results suggest a blunted adrenal cortisol response to ACTH in children with type-1 diabetes, which might influence the control of the disease and play a role in the development of its chronic complications.