Abstract: Microbial polyesters such as polyhydroxyalkanoates (PHAs) are biopolymers with unique physicochemical and thermal properties that can replace synthetic polymers from the environment. The ability of these polymers to aid multiple processes in pharmaceuticals, drug delivery systems, and bioplastic materials has increased their worth in the polymer industry. Polyhydroxyalkanoate synthase (PhaC) has a crucial role in the biosynthesis of PHA and is produced by various microbes. Pseudomonas strains have a high potential to produce PhaC.