Abstract: Obesity increases the incidence of several metabolic disorders such as diabetes, hypertension, dyslipidemia, atherosclerosis, and cancer. Oxidative stress has been considered one of the mechanisms linking obesity to these pathologies. This study evaluated total antioxidant capacity, malondialdehyde in relation to lipid profile and Body Mass Index in obese Adults within Nnewi metropolis. A total of 198 apparently healthy subjects were recruited in this study, divided according to their BMI into three groups: group A (BMI <25, normal weight), group B (25 ≤ BMI <30, overweight) which had sixty-four participants respectively and group C (BMI ≥ 30, obesity) which had 70 participants. 6mL of blood was obtained from each subject between the hours of 08.00-10.00 after overnight fast and dispensed into plain bottles and allowed to clot, then serum was separated and aliquoted into dry plain plastic screw-capped containers and stored frozen at -20°C prior to analysis using spectrophotometer.