Abstract: The article presents the current state of knowledge about the SARS-CoV-2 virus and COVID-19 disease in such a way as to provide the basis for the modernization of the flight and airport management system in such a way as to maximally protect passengers and crew from infection and transport of sick people from one country to another. To this end, a method of organizational flight preparation, methods of diagnosing passengers, methods of securing passengers in the field of distance by means of various several different personal protective equipment was developed in order to limit contacts of neighboring passengers in terms of time of exposure to the virus. Several methods of passenger protection and isolation on board were presented for simultaneous use. Innovative measuring and control equipment, personal protective equipment and test methods before, during and after the flight were presented, and practical solutions in crisis situations were proposed. The article contains the state of research and a practical guide on how to accomplish subsequent tasks to achieve flight goals in terms of COVID-19 safety.