Abstract: Background: Liposarcoma is soft tissue malignancy with an incidence of 9.8% of all musculoskeletal sarcomas. However, the rare incidence causes little case publication or clinical clinicatology in these tumors, especially in Indonesia. Objective: To determine the characteristics of liposarcoma in the Anatomical Pathology Laboratory of the USU Medical Faculty and the H. Adam Malik General Hospital Medan in 2016-2018.