Abstract: Background: Cutaneous squamous cell carcinoma (cSCC) is the malignant tumor derived from the keratinocytes of the epidermis. It is the second most common skin cancer in Indonesia. The infiltration of tumor-infiltrating lymphocytes (TILs) had been studied and related with the prognostic factor for many solid tumors. The research about TILs with Hematoxylin&Eosin staining for cSCC has not been studied until nowadays.