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IJSRP, Volume 7, Issue 7, July 2017 Edition [ISSN 2250-3153]

      Rakesh Singh Chauhan, Rahasya Mani Mishra, Naveen Kango, Santosh Agnihotri, Awadhraj Singh

Abstract: In the mammalian host, invasion of the hepatocytes is the first step towards developing malaria disease. There are some signals which are exchanged between host and parasite. During early liver stage development, a sporozoite surface protein (CSP) is introduced in the hepatocytes cytoplasm. CSP then shuttles into and out of nucleus of hepatocytes and changes the host transcription profile. CSP export into the cytoplasm of infected hepatocyte requires the presence of a conserved pentameric motif-PEXEL (Plasmodium export elements) motifs. The CS protein out compete with the NFkb for nuclear import and down regulate the host genes regulated by NFkb which are involved in inflammation. These proteins could serve as good candidate for the drug development against malaria parasite. Marti et al. identified 22 sporozoite stage proteins in P. falciparum that had putative PEXEL motif. It has been identified that protein Pb122500 also contains that PEXEL motif and has a putative serine–thrionine kinase domain (so it is a drug candidate). The focus of current research is to study implications of Pb122500 gene as potential vaccine candidate by cloning and expressing the protein, characterizing the proteins, raise sera against them and try to localize these proteins in hepatocyte cells and find out further the host proteins interacting with these proteins so that we could find new antigen for vaccine against hepatic stages.

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Reference this Research Paper (copy & paste below code):

Rakesh Singh Chauhan, Rahasya Mani Mishra, Naveen Kango, Santosh Agnihotri, Awadhraj Singh (2017); Liver stage Plasmodium Protein Pb122500 and Implication for Vaccine Design; Int J Sci Res Publ 7(7) (ISSN: 2250-3153).



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