Abstract: A field study was conducted at Makurdi, Nigeria, during 2011 and 2012 cropping seasons to determine the responses of seven cowpea varieties to four growth regulators with respect to nodulation and yield. Aluminum tetraflouride (AlF4) and 2, 4-D were applied at 200mg/L; while coconut milk and potassium nitrate (KNO3) were applied at 15%; all applications as foliar spray. Parameters evaluated per plant included: number of nodules, number of branches, nodule weight (g), number of pods, number of leaves, pod length (cm), pod weight (g) and seed weight (kg/ha). Results showed that coconut milk at 15% produced significantly higher nodule number, number of leaves, pods, pod length, and pod weight than KNO3, 2, 4-D, AIF4 and control treatments.