International Journal of Scientific and Research Publications

IJSRP, Volume 12, Issue 6, June 2022 Edition [ISSN 2250-3153]


Punica. Granatum peel ethanol extract may exhibit liver protection activity against hepatotoxicity induced by paracetamol in rats
      Sara A. M1., Hala E. A, Huda O. Ali, Nagla M. Mohmmed, Mohammed Ahmed A. Ahmed, Manal H. Salih, Samia H. Abdel Rahman, and, Tarig H. A. Bilal
Abstract: Background: Paracetamol is extensively used analgesic and antipyretic drug. High dose of paracetamol is well known as hepatotoxicity motivator. In order to maintain the hepatic heath, the effect of PGPE as hepatoprotective plant evaluated. Materials and methods: 35 male rats weighing 150-200 g, sorted randomly into 5 groups, (A, B, C, D and E), received orally, normal saline (A and B), Silymarin 80mg/kg (C), 250 mg/kg PGPE (D), 500 mg/kg (E) for 7 days, on day 8 hepatotoxicity induced by single dose of paracetamol 750mg/kg. after 24 hours of fasting, rats were sacrificed, blood samples collected for determination of hematology and biochemistry profile. Liver tissue samples were taken in 10% formalin for histopathology examination. Results: the high elevation of liver enzymes (ALT, AST and ALP, occurred by the single high dose of paracetamol was remarkably reversed by PGPE administration, while serum level of albumin was not significantly altered. Total WBCs count massively lowered by paracetamol administration, and got worse by dosing 500mg/kg PGPE. RBCs, Hb and PCV values expressively reduced by paracetamol and more reduction induced by 500 mg/kg of PGPE.

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Sara A. M1., Hala E. A, Huda O. Ali, Nagla M. Mohmmed, Mohammed Ahmed A. Ahmed, Manal H. Salih, Samia H. Abdel Rahman, and, Tarig H. A. Bilal (2022); Punica. Granatum peel ethanol extract may exhibit liver protection activity against hepatotoxicity induced by paracetamol in rats; International Journal of Scientific and Research Publications (IJSRP) 12(6) (ISSN: 2250-3153), DOI: http://dx.doi.org/10.29322/IJSRP.12.06.2022.p12616
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