Abstract: Tramadol abuse is a significant problem among young people especially those within and slightly above adolescent age. The rate of tramadol abuse among young people is increasingly high and is linked with numerous harmful effects. However, there is still dearth of studies exploring predictors of tramadol abuse among young people in Nigeria. Therefore, this study examined the predictive role of self-esteem, peer influence and family relationship in tramadol abuse among young people undergoing rehabilitation at Rescue City Medical Centre.