Abstract: An artificial neural network (ANN) based maximum power point tracking (MPPT) technique for proton exchange membrane fuel cell (PEMFC) is analyzed and proposed in this paper. The proposed ANN technique employs Radial basis function network (RBFN) based MPPT strategy to extract the maximum available power from fuel cell in different operating condition. In order to achieve high voltage rating, a novel high step-up DC/DC converter is incorporated in the proposed configuration. To validate the performance of the proposed configuration, the result is compared with different DC/DC converter and MPPT control strategy. The proposed system is simulated in MATLAB/Simulink platform to analyze the performance of the system.