Abstract: Mosquitoes constitute a serious public health menace, resulting in millions of deaths worldwide each year. Emergence of insecticide resistance strains of the mosquitoes poses a serious threat and hence calls for alternative control measures. This study assessed the larvicidal efficacy of the ethanol and aqueous extracts of leaves of Thevetia peruviana against the larvae of malaria vector Anopheles mosquitoes. Bioassay was carried out on 2nd and 3rd instar larval stages of Anopheles mosquitoes. The toxicity effect of the treatment was measure in terms of mortality, which was observed for 72 hours, at 24 hours interval.