Abstract: Background: Most of the newer concepts in Nephrology developed in the 19th and 20th century. Progression of renal failure is an area of Nephrology where our understanding has improved appreciably in the last century but still our knowledge is like a drop in ocean. We have ample of evidence that progression of renal failure can be slowed down but we still need more definite information whether established renal failure can be reversed. This pilot clinical study was planned to explore the therapeutic potential of salicinol in retardation of chronic kidney disease progression and anti-atherosclerotic property by looking for if reduction in CIMT is possible.