Abstract: Background: Schizophrenia is related with physiological condition. It affects brain sections including the prefrontal cortex, the basal ganglia as well as limbic system. There are certain neurotransmitters present in the brain such as dopamine. When level of dopamine is disturbed it causes schizophrenia. Environmental factors like stress, depression and anxiety also contribute to schizophrenia. Several drugs including first and second generation are available to provide treatment against schizophrenia. Second generation drugs have better results and fewer side effects than first generation. Clozapine is second generation drug which was recommended as best drug for schizophrenia.