Abstract: In the present investigations, the anticarcinogenic activity of Andrographis paniculata leaves and whole plant extracts was evaluated using two stage protocol in skin papillioma model in Swiss albino mice . It is a widely used medicinal plant and used in various indigenous systems of medicine. The prevention of papillomas in DMBA + Andrographis paniculata leaves and whole Plant extract + croton oil treated group was observed in The mice which was initiated by DMBA followed by croton oil .