Abstract: Gallstones are the most common biliary pathology. For decades, there has been a discussion, whether thyroid disorders could cause gallstone disease due to the low bile flow in hypothyroid subjects. The present study was conducted on 200 patients of gallstone diseases admitted in the Department of Surgery, Regional Institute of Medical Sciences Hospital, Imphal, after taking due permission from the Institutional Ethics Committee. Among the 43 hypothyroid patients with gallstones, 38 were found to be in subclinical state. Females showed predominance with 65.7%. Subclinical hypothyroid was more in the age group 46-55 years. Hypothyroidism in choledocholithiasis patients was more in subclinical state. When treating patients with gallstone disease, clinicians should be aware of the possible hypothyroid background and consider examining the thyroid function, atleast in elderly female patients.