Abstract: The objective of this study is to explore the major factors that influence turnover intention among permanent employees in Dire Dawa Administration in three government bureaus namely; trade, industry and investment bureau, land development management bureau and urban development bureau. It aims to identify the most significant determinants influencing the employees' turnover intention in these government bureaus. A total of 286 permanent employees as a respondent were involved in this study by using a census method. Three independent variables that are promotion opportunities, professionalism and organizational commitment were included to assess their relationship with dependent variable which is turnover intention. Data was obtained through structured questioners and has been analyzed using Statistical Package for Social Sciences (SPSS) version 20. The regression analysis of promotion opportunities, professionalism and organizational commitment on turnover intentions indicated negative and significant relationship. This proved that all factors are indirectly related to employees' turnover intention which is consistent with the previous other research findings. The finding of this study also suggested that 'promotion opportunities' are the most significant factor influencing employees to quit their jobs among the permanent employees working in these three government bureaus in Dire Dawa Administration. Organizational commitment and professionalism played the second and third rank, respectively, for the turnover intention of employees. Therefore, the respective government bodies need to give high attention to �promotion opportunities, professionalism and organizational commitment' so as to hold the experienced and qualified employees in the long run.