Abstract: This review is focused upon the increased efficacy led by composition upgradation of standard COQ10 supplement for male fertility, with Ubiquinol – the reduced form of coenzyme Q10. The rates of male infertility in less industrialized nations are markedly higher and infectious diseases are responsible for a greater proportion of infertility. Dietary supplementation with CoQ10 results in increased levels of Ubiquinol within circulating lipoproteins and increased resistance of human low-density lipoproteins to the initiation of lipid peroxidation. Supplementation with CoQ10 at pharmacological doses was capable of improving sperm functions by increasing sperm cell motility, thereby increasing male fertility. Finally, the findings on the implications of CoQ10 in seminal fluid integrity and sperm cell motility are summarized.