Abstract: Microorganisms are important in histopathology because vast majority of pathological basis of diseases are either direct or indirect effects of pathogens. Therefore demonstration of microorganisms in tissue sections is essential in complementing clinical findings, identification of the infecting organism, cost effectiveness and administering prompt treatment regimen where applicable. Tissue detection of microorganisms using molecular techniques is highly specific and sensitive; however, they are expensive to procure and maintain in a resource-limited laboratory mostly in the developing countries. Hence, the use of conventional light microscope along with the use of general and different special histopathological stains are essential to assist the Histopathologist in providing an opinion as to the type of microorganism causing the disease condition.