IJSRP, Volume 8, Issue 6, June 2018 Edition [ISSN 2250-3153]
B.Sreekanth, Dr C.M.Bhaskar Reddy, Dr S.G. Manjunatha
The main aim and objective of this research paper is to prepare pharmacophore 1, 2- amino alcohols. Amino alcohols are prepared by ring opening with nitrogen nuclophiles from Cyclicsulfates which was consequentialised via asymmetric dihydroxylation of the corresponding alkenes. 1,2-amino alcohols prepared by ring opened with nitrogen nuclophiles from carbonates which was derived via asymmetric dihydroxylation of the corresponding alkenes. The opening occurs in the generally activated position with overall yields of 70-80% . Similarly, synthesised syn-amino alcohols from syn-diols. These compounds are more useful to cure infections obtained from Gram positive and Gram negative Bacteria in human beings.