Abstract: Medical expulsion therapy is being used to treat ureteric stones after understanding the pathophysiology of the ureter. The objective of this study was to find out the efficacy of alfa blockers (Prazocin) and calcium channel blockers (Nifedipine) in management of ureteric stones. A prospective study was done in patients who presented with ureteric stones to THP from 1st June 2009 to 31st October 2011. We randomized patients into three groups and identified the patients who were treated with Medical Expulsive Therapy (MET) for urolithiasis. X-ray KUB reports at the diagnosis and after 1 month of treatment with MET were collected. Findings of X-ray KUBs were assessed according to the MET type. A total of 105 patients with mean age of 41.35 years (+/- 12.98) were included. Out of 105, 48 have been given Prazosin 0.5 mg bd (group-A). Nifedipine 10mg bd (group-B) has been given to 29. Both groups have been given Diclofenac Na 50mg tds with Omeprazole 20mg bd. The other 28 have given only Diclofenac and Omeprazole (group-C)