Abstract: Malaria has protean clinical manifestations and renal complications, particularly acute kidney injury that could be life threatening. This study was a prospective study of 50 patients with malaria-associated AKI at our hospital. Smear positive and Parasite V and F positive malaria patients with AKI as defined by RIFLE (Risk, Injury, Failure, Loss of kidney function, and End-stage kidney disease) classification were selected to evaluate the clinical profile and outcome. Out of 50 patients in our study 38 were males and 12 were females. 42% were between 26-40 years. Fever was the most common presenting complaint (100%), followed by chills and rigors (90%), headache (74%), vomiting (70), myalgia (60%), altered sensorium (30%) and discolouration of sclera (36%). Pallor (62%) was the most common sign followed by splenomegaly (62%), icterus (40%) and hepatomegaly (34%). Artemesinin combination therapy was given for all patients and renal replacement therapy was given to 12 (24%) patients. We had a mortality of 12%, all of them had multiple complications. Acute kidney injury in malaria occurred most commonly in plasmodium falciparum 70% infected patients. Applying RIFLE criteria helps in early identification of high risk cases, so that prompt treatment is instituted early, thereby reducing the mortality rate.