Abstract: Knowledge workers retention is increasingly being recognized as a source of entrepreneurial success. Thus, we argue that the sustainability of such knowledge-based success depends on the effective and efficient management of knowledge workers plateauing and turnover. This study therefore sought to examine why knowledge workers experience career plateauing and show intention to quit, and the relationship between entrepreneurial success and the type of plateauing/turnover. The data generated were analysed using Z-score and regression analysis. It was found that reduced organizational hierarchies, reduced promotion opportunities, and fewer competitive positions are the factors that influence plateauing, while entrepreneurial success has a negative relationship with the significant types of plateauing. Also, lack of recognition/competitive reward system, inadequate training/development opportunities, and managerial/leadership style are the factors that influence turnover, while a negative relationship was found to exist between entrepreneurial success and the significant types of turnover. It is therefore pertinent for managers to assess and understand the factors influencing plateauing and turnover, and the types of plateauing and turnover that are prevalent in their enterprises. This knowledge will certainly help to minimize the effects of the factors and types of plateauing/ turnover on entrepreneurial success.