Abstract: This study sought to find out students’ challenges face during the teaching and learning of acid-base titrition. The research design used the study was a case study. The study took place at Berekum Presbyterian Senior High Schools in the Bono Region of Ghana. This study adopted social constructivism theory of learning. The social constructivism involves the engagement of students in a process of shared meaning-making, guided by the teacher. The target population in the study consisted of thirty chemistry final year students of 2014 / 2015 academic year from Presbyterian Senior High School Berekum in the Brong Ahafo Region.